Outline
Illustration of the chronic dose-limiting toxicity (DLT) concept. (*)... | Download Scientific Diagram
Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol | BMJ Open
Dose escalation algorithm for trial part 1. DLT, dose-limiting... | Download Scientific Diagram
Study design for dose-escalation cohorts and DLT rate (as calculated by... | Download Scientific Diagram
Three-plus-three dose escalation design. DLT, dose-limiting toxicity;... | Download Scientific Diagram
Diagram of the inter-subject or inter-cohorts' escalation. DLT:... | Download Scientific Diagram
Study Design. DLT-dose limiting toxicity; MTD-maximum tolerated dose | Download Scientific Diagram
Cancers | Free Full-Text | Maximum Tolerated Dose and Anti-Tumor Activity of Intraperitoneal Cantrixil (TRX-E-002-1) in Patients with Persistent or Recurrent Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer: Phase I
A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia | PLOS ONE
A Bayesian Logistic Model with Covariate to Identify Optimal Dose for Heterogeneous Population in Phase I Oncology Trial Xin Wei, Mike Branson Celgene. - ppt download
Flexibility of the BLRM in Dose-Escalation Trials
Study protocol: phase 1 dose escalating study of Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) with oxaliplatin in peritoneal metastasis
Cancers | Free Full-Text | Ibrutinib Associated with Rituximab-Platinum Salt-Based Immunochemotherapy in B-Cell Lymphomas: Results of a Phase 1b-II Study of the LYSA Group
Cureus | Phase 1 First-in-Human Dose Escalation and Dose Expansion Study of KLS-1 (64Zinc Aspartate) in Patients With Cancer and Neurodegenerative Diseases | Article
Study design. PK, pharmacokinetics; DLT, dose- limiting toxicity | Download Scientific Diagram
Adaptive designs for dual-agent phase I dose-escalation studies | Nature Reviews Clinical Oncology
Recommended dosages in each arm. DLT, dose-limiting toxicity; RD,... | Download Scientific Diagram
Entropy | Free Full-Text | Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding
DLT - Dose Limiting Toxicity - determined by phase 1 studies
DURVIT': a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment | BMC Cancer | Full Text
Dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) in Phase... | Download Table
Safety and pharmacokinetics of milademetan, a MDM2 inhibitor, in Japanese patients with solid tumors: A phase I study - Takahashi - 2021 - Cancer Science - Wiley Online Library
Determining drug dose in the era of targeted therapies: playing it (un)safe? | Blood Cancer Journal
Phase I trials - memoinOncology
Dose Limiting Toxicities (DLT) DOSE LIMITING TOXICITIES (DLT) Example: Dose escalation will proceed within each cohort according
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Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
Dose-Finding Schemes in Clinical Trials
